(2S)-3-propan-2-ylpyrrolidine-2-carboxylic acid

反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of diethyl-3-isopropylpyrrolidine-2,2-dicarboxylate (Example 39, Step A, 2.27 g, 8.81 mmol) in 6 M HCl (50 mL) was heated to reflux. The solution turned from pale yellow in color to orange with addition of acid, then to brown upon heating. The mixture was stirred overnight at 50° C. Solvent was removed in vacuo to afford the title compound (a mixture of four diastereomers) as a brown oil which was carried on crude. LCMS (M+H): 158.0. orange with addition of acid to brown upon heating Solvent was removed in vacuo

反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of diethyl-3-isopropylpyrrolidine-2,2-dicarboxylate (Example 39, Step A, 2.27 g, 8.81 mmol) in 6 M HCl (50 mL) was heated to reflux. The solution turned from pale yellow in color to orange with addition of acid, then to brown upon heating. The mixture was stirred overnight at 50° C. Solvent was removed in vacuo to afford the title compound (a mixture of four diastereomers) as a brown oil which was carried on crude. LCMS (M+H): 158.0. orange with addition of acid to brown upon heating Solvent was removed in vacuo

反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of diethyl-3-isopropylpyrrolidine-2,2-dicarboxylate (Example 39, Step A, 2.27 g, 8.81 mmol) in 6 M HCl (50 mL) was heated to reflux. The solution turned from pale yellow in color to orange with addition of acid, then to brown upon heating. The mixture was stirred overnight at 50° C. Solvent was removed in vacuo to afford the title compound (a mixture of four diastereomers) as a brown oil which was carried on crude. LCMS (M+H): 158.0. orange with addition of acid to brown upon heating Solvent was removed in vacuo