2-甲基磺酰基苯甲酰基 氯化物

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following the procedure as described in Example 2, making variations only as required to use 2-methanesulfonylbenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 9% yield; m.p. 239-242° C.; 1H NMR (DMSO-d6, 300 MHz) δ 8.64 (t, J=5.8 Hz, 1H), 8.59 (s, 1H), 8.35 (d, J=7.8 Hz, 1H), 8.13 (d, J=7.8 Hz, 1H), 7.80 (t, J=7.8 Hz, 1H), 7.33-7.19 (m, 6H), 4.38 (d, J=5.8 Hz, 2H), 3.26 (s, 3H), 2.51 (s, 3H); MS (ES+) m/z 430.1 (M+1).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following the procedure as described in Example 2, making variations only as required to use 2-methanesulfonylbenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 9% yield; m.p. 239-242° C.; 1H NMR (DMSO-d6, 300 MHz) δ 8.64 (t, J=5.8 Hz, 1H), 8.59 (s, 1H), 8.35 (d, J=7.8 Hz, 1H), 8.13 (d, J=7.8 Hz, 1H), 7.80 (t, J=7.8 Hz, 1H), 7.33-7.19 (m, 6H), 4.38 (d, J=5.8 Hz, 2H), 3.26 (s, 3H), 2.51 (s, 3H); MS (ES+) m/z 430.1 (M+1).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following the procedure as described in Example 2, making variations only as required to use 2-methanesulfonylbenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 9% yield; m.p. 239-242° C.; 1H NMR (DMSO-d6, 300 MHz) δ 8.64 (t, J=5.8 Hz, 1H), 8.59 (s, 1H), 8.35 (d, J=7.8 Hz, 1H), 8.13 (d, J=7.8 Hz, 1H), 7.80 (t, J=7.8 Hz, 1H), 7.33-7.19 (m, 6H), 4.38 (d, J=5.8 Hz, 2H), 3.26 (s, 3H), 2.51 (s, 3H); MS (ES+) m/z 430.1 (M+1).