1-甲基-1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Triethylamine (70 μL, 0.50 mmol) was added to a solution of the hydrochloride salt of (6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-amine (70 mg, 0.167 mmol) and 4-nitrophenyl chloroformate (34 mg, 0.167 mmol) in tetrahydrofuran (2 mL) at 0° C. After 15 min, a solution of 1-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (31 mg, 0.167 mmol) in dichloromethane (2 mL) and triethylamine (93 μL, 0.67 mmol) were added and the mixture was allowed to warn to ambient temperature. After 4 h, saturated aqueous sodium carbonate was added and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium bicarbonate (3×), saturated brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% dichloromethane→90% dichloromethane/methanol) gave the title compound (33 mg). MS 555.2107 (M+1). to warn to ambient temperature After 4 h the mixture was extracted with ethyl acetate The organic layer was washed with saturated aqueous sodium bicarbonate (3×), saturated brine dried over magnesium sulfate filtered concentrated Purification by silica gel chromatography (100% dichloromethane→90% dichloromethane/methanol)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Palladium (10% on carbon; 1.0 g) was added to a solution of benzyl 1-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate (7.82 g, 24.6 mmol) in ethanol (100 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 2 h, methanol (50 mL) was added to the reaction mixture and the mixture was continued to be stirred under hydrogen (1 atm). After 4 days, the mixture was filtered through celite, washed with acetone and concentrated. The mixture was diluted in acetic acid (50 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 2 h, the mixture was filtered through celite, and concentrated to give the acetate salt of the title compound (2.98 g). MS 184.1 (M+1). The reaction vessel was evacuated back-filled with nitrogen (3×) back-filled with hydrogen (1 atm) methanol (50 mL) was added to the reaction mixture After 4 days the mixture was filtered through celite washed with acetone concentrated The mixture was diluted in acetic acid (50 mL) The reaction vessel was evacuated back-filled with nitrogen (3×) back-filled with hydrogen (1 atm) After 2 h the mixture was filtered through celite concentrated