N-BENZYL-N-(2-METHOXYETHYL)AMINE

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and benzyl-(2-methoxy-ethyl)-amine in dichloromethane. MS-ISP: 575 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and benzyl-(2-methoxy-ethyl)-amine in dichloromethane.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: According to the method of Example 13, 2-(4-methylphenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-benzyl-2-methoxyethylamine were used as raw materials for synthesis, to obtain yellow solid powder, yield 54.6%. m.p. 220-222° C., ESm/z: 398[M+H]+, 1H NMR(CDCl3, 400 MHz)δ: 1.14(t, 1.5H, J=7.00 Hz), 1.17(t, 1.5H, J=7.00 Hz), 2.36(s, 1.5H), 2.37(s, 1.5H), 2.52(s, 1.5H), 2.54(s, 1.5H), 3.35(q, 1H, J=7.00 Hz), 3.52(q, 1H, J=7.00 Hz), 4.15(s, 1H), 4.24(s, 1H), 4.57(s, 1H), 4.61(s, 1H), 7.05-7.19(m, 1H), 7.22-7.36(m, 9H), 7.47-7.62(m, 1H), 8.13-8.29(m, 1H). were used as raw materials for synthesis to obtain yellow solid powder, yield 54.6%

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: According to the method of Example 13, 2-(4-methylphenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-benzyl-2-methoxyethylamine were used as raw materials for synthesis, to obtain yellow solid powder, yield 54.6%. m.p. 220-222° C., ESm/z: 398[M+H]+, 1H NMR(CDCl3, 400 MHz)δ: 1.14(t, 1.5H, J=7.00 Hz), 1.17(t, 1.5H, J=7.00 Hz), 2.36(s, 1.5H), 2.37(s, 1.5H), 2.52(s, 1.5H), 2.54(s, 1.5H), 3.35(q, 1H, J=7.00 Hz), 3.52(q, 1H, J=7.00 Hz), 4.15(s, 1H), 4.24(s, 1H), 4.57(s, 1H), 4.61(s, 1H), 7.05-7.19(m, 1H), 7.22-7.36(m, 9H), 7.47-7.62(m, 1H), 8.13-8.29(m, 1H). were used as raw materials for synthesis to obtain yellow solid powder, yield 54.6%

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and benzyl-(2-methoxy-ethyl)-amine in dichloromethane. MS-ISP: 575 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and benzyl-(2-methoxy-ethyl)-amine in dichloromethane.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and benzyl-(2-methoxy-ethyl)-amine in dichloromethane.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: According to the method of Example 13, 2-(4-methylphenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-benzyl-2-methoxyethylamine were used as raw materials for synthesis, to obtain yellow solid powder, yield 54.6%. m.p. 220-222° C., ESm/z: 398[M+H]+, 1H NMR(CDCl3, 400 MHz)δ: 1.14(t, 1.5H, J=7.00 Hz), 1.17(t, 1.5H, J=7.00 Hz), 2.36(s, 1.5H), 2.37(s, 1.5H), 2.52(s, 1.5H), 2.54(s, 1.5H), 3.35(q, 1H, J=7.00 Hz), 3.52(q, 1H, J=7.00 Hz), 4.15(s, 1H), 4.24(s, 1H), 4.57(s, 1H), 4.61(s, 1H), 7.05-7.19(m, 1H), 7.22-7.36(m, 9H), 7.47-7.62(m, 1H), 8.13-8.29(m, 1H). were used as raw materials for synthesis to obtain yellow solid powder, yield 54.6%

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and benzyl-(2-methoxy-ethyl)-amine in dichloromethane. MS-ISP: 575 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Then treatment with triethylamine and benzyl-(2-methoxy-ethyl)-amine in dichloromethane.