α-酮-γ-甲硫基丁酸 钠盐

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 2-(7-methyl-4-(piperazin-1-yl)quinazolin-2-yl)phenol (200 mg, 0.63 mmol), sodium 4-methylsulfanyl-2-oxo-butyrate (160 mg, 0.94 mmol), BOP (414 mg, 0.94 mmol), and triethylamine (348 μL, 2.5 mmol) in 2.1 mL of CH2Cl2 was stirred at room temperature for 1 h. After adding saturated NaHCO3 solution, the mixture was extracted with CH2Cl2. The organic extracts were dried over Na2SO4 and concentrated to give 1-(4-(2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl)piperazin-1-yl)-4-(methylthio)butane-1,2-dione. LC/MS: m/z 451.2 (M+H)+ at 3.10 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)). the mixture was extracted with CH2Cl2 The organic extracts were dried over Na2SO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 2-(7-methyl-4-(piperazin-1-yl)quinazolin-2-yl)phenol (200 mg, 0.63 mmol), sodium 4-methylsulfanyl-2-oxo-butyrate (160 mg, 0.94 mmol), BOP (414 mg, 0.94 mmol), and triethylamine (348 μL, 2.5 mmol) in 2.1 mL of CH2Cl2 was stirred at room temperature for 1 h. After adding saturated NaHCO3 solution, the mixture was extracted with CH2Cl2. The organic extracts were dried over Na2SO4 and concentrated to give 1-(4-(2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl)piperazin-1-yl)-4-(methylthio)butane-1,2-dione. LC/MS: m/z 451.2 (M+H)+ at 3.10 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)). the mixture was extracted with CH2Cl2 The organic extracts were dried over Na2SO4 concentrated