3-氨基-3-苯基丁烷-1-醇

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The product of Example 457D (0.886 g, 4.68 mmol) in methanol (15 ml) at room temperature was reacted with 6N NaOH (15 ml) and the resulting mixture heated under nitrogen at 80° C. overnight. The methanol was evaporated in vacuo and the aqueous residue isolated by extraction with dichloromethane. The combined extracts were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.717 g, 93%) as a pale yellow solid used without further purification. The methanol was evaporated in vacuo the aqueous residue isolated by extraction with dichloromethane The combined extracts were dried over sodium sulfate concentrated in vacuo

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The product of Example 457D (0.886 g, 4.68 mmol) in methanol (15 ml) at room temperature was reacted with 6N NaOH (15 ml) and the resulting mixture heated under nitrogen at 80° C. overnight. The methanol was evaporated in vacuo and the aqueous residue isolated by extraction with dichloromethane. The combined extracts were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.717 g, 93%) as a pale yellow solid used without further purification. The methanol was evaporated in vacuo the aqueous residue isolated by extraction with dichloromethane The combined extracts were dried over sodium sulfate concentrated in vacuo