甲基 n-methylethanimidate

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of methyl N-methylacetimidate (8.7 g, 0.1m) in toluene (90 ml.) was added cyclohexylamine (10.5 g, 0.105m). After 72 hours at room temperature and 32 hours heating at 60°-70° C the solvent was removed by evaporation to yield an oil which crystallised on cooling. Chromatography on alumina using ether as eluent afforded N-cyclohexyl-N1 -methylacetamidine as a colourless solid (11 g), or m.p. 108.5° - 109.5° C. 32 hours heating at 60°-70° C the solvent was removed by evaporation to yield an oil which crystallised on cooling

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of methyl N-methylacetimidate (8.7 g, 0.1m) in toluene (90 ml.) was added cyclohexylamine (10.5 g, 0.105m). After 72 hours at room temperature and 32 hours heating at 60°-70° C the solvent was removed by evaporation to yield an oil which crystallised on cooling. Chromatography on alumina using ether as eluent afforded N-cyclohexyl-N1 -methylacetamidine as a colourless solid (11 g), or m.p. 108.5° - 109.5° C. 32 hours heating at 60°-70° C the solvent was removed by evaporation to yield an oil which crystallised on cooling