1-(2-氯苯基)-2-甲基丙-1-one

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 1-(2-chlorophenyl)-2-methylpropan-1-ol (1.5 g in 15 mL DCM) was added is to a suspension of PCC (2.62 g in 30 mL DCM) at 25° C., monitoring the reaction by TLC. After 2 h, Et2O (120 mL) was added and the reaction mixture was stirred for 15 min. The supernatant was decanted, dried (Na2SO4) and concentrated under vacuum. Purification by flash chromatography (SiO2, 0-10% EtOAc in hexanes) gave the title compound as a clear colorless oil (1.24 g, 82%). 1H NMR (400 MHz, CDCl3) δ ppm 7.41-7.27 (m, 4H), 3.37-3.30 (m, 1H), 1.19 (d, J=6.8 Hz, 6H). the reaction by TLC The supernatant was decanted dried (Na2SO4) concentrated under vacuum Purification by flash chromatography (SiO2, 0-10% EtOAc in hexanes)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 1-(2-chlorophenyl)-2-methylpropan-1-ol (1.5 g in 15 mL DCM) was added is to a suspension of PCC (2.62 g in 30 mL DCM) at 25° C., monitoring the reaction by TLC. After 2 h, Et2O (120 mL) was added and the reaction mixture was stirred for 15 min. The supernatant was decanted, dried (Na2SO4) and concentrated under vacuum. Purification by flash chromatography (SiO2, 0-10% EtOAc in hexanes) gave the title compound as a clear colorless oil (1.24 g, 82%). 1H NMR (400 MHz, CDCl3) δ ppm 7.41-7.27 (m, 4H), 3.37-3.30 (m, 1H), 1.19 (d, J=6.8 Hz, 6H). the reaction by TLC The supernatant was decanted dried (Na2SO4) concentrated under vacuum Purification by flash chromatography (SiO2, 0-10% EtOAc in hexanes)