5-甲基-5-(2-苯基乙基)咪唑烷-2,4-二酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 54.6 5-methyl-5-phenethyl-hydantoin (0.25 Mol) are reacted with 30 g sodium hydroxide (0.75 Mol) and 150 ml water for 3.5 hours in an autoclave at an oil bath temperature of 180° C. After cooling, 350 ml H2O are added and the clear, light brown solution adjusted with hydrochloric acid to pH 7.0. The white precipitate is suctioned off, washed with 20 mg H2O and dried in a vacuum drying cabinet at 65° C. The product is recrystallized twice from water. After cooling washed with 20 mg H2O dried in a vacuum drying cabinet at 65° C The product is recrystallized twice from water

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 54.6 5-methyl-5-phenethyl-hydantoin (0.25 Mol) are reacted with 30 g sodium hydroxide (0.75 Mol) and 150 ml water for 3.5 hours in an autoclave at an oil bath temperature of 180° C. After cooling, 350 ml H2O are added and the clear, light brown solution adjusted with hydrochloric acid to pH 7.0. The white precipitate is suctioned off, washed with 20 mg H2O and dried in a vacuum drying cabinet at 65° C. The product is recrystallized twice from water. After cooling washed with 20 mg H2O dried in a vacuum drying cabinet at 65° C The product is recrystallized twice from water

反应条件: temp:40.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A suspension of 144.1 g (1.5 Mol) ammonium carbonate in 800 ml methanol/water 1:1 mixture is prepared in a 2 liter three-necked flask. At a temperature of 20° C. 43.2 ml (1.1 Mol) hydrocyanic acid are added within 1 minute. 152.8 g (1.0 Mol) 4-phenyl-2-butanol (benzyl acetone) are then added dropwise, leading to a slight exothermic reaction (temperature increase to ca. 30° C.). The white emulsion is maintained at 40° C. for 1 hour and then for 2.5 hours at 60° C. The precipitate is suction filtered, washed twice with 50 ml methanol/H2O 1:1 and dried in a vacuum at 60° C. is prepared in a 2 liter three-necked flask At a temperature of 20° C leading to a slight exothermic reaction (temperature increase to ca. 30° C.) filtered washed twice with 50 ml methanol/H2O 1:1 dried in a vacuum at 60° C.

反应条件: temp:40.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A suspension of 144.1 g (1.5 Mol) ammonium carbonate in 800 ml methanol/water 1:1 mixture is prepared in a 2 liter three-necked flask. At a temperature of 20° C. 43.2 ml (1.1 Mol) hydrocyanic acid are added within 1 minute. 152.8 g (1.0 Mol) 4-phenyl-2-butanol (benzyl acetone) are then added dropwise, leading to a slight exothermic reaction (temperature increase to ca. 30° C.). The white emulsion is maintained at 40° C. for 1 hour and then for 2.5 hours at 60° C. The precipitate is suction filtered, washed twice with 50 ml methanol/H2O 1:1 and dried in a vacuum at 60° C. is prepared in a 2 liter three-necked flask At a temperature of 20° C leading to a slight exothermic reaction (temperature increase to ca. 30° C.) filtered washed twice with 50 ml methanol/H2O 1:1 dried in a vacuum at 60° C.

反应条件: temp:40.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A suspension of 144.1 g (1.5 Mol) ammonium carbonate in 800 ml methanol/water 1:1 mixture is prepared in a 2 liter three-necked flask. At a temperature of 20° C. 43.2 ml (1.1 Mol) hydrocyanic acid are added within 1 minute. 152.8 g (1.0 Mol) 4-phenyl-2-butanol (benzyl acetone) are then added dropwise, leading to a slight exothermic reaction (temperature increase to ca. 30° C.). The white emulsion is maintained at 40° C. for 1 hour and then for 2.5 hours at 60° C. The precipitate is suction filtered, washed twice with 50 ml methanol/H2O 1:1 and dried in a vacuum at 60° C. is prepared in a 2 liter three-necked flask At a temperature of 20° C leading to a slight exothermic reaction (temperature increase to ca. 30° C.) filtered washed twice with 50 ml methanol/H2O 1:1 dried in a vacuum at 60° C.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 54.6 g 5-methyl-5-phenethyl-hydantoin (0.25 Mol) are reacted with 30 g sodium hydroxide (0.75 Mol) and 150 ml water for 3.5 hours in an autoclave at an oil bath temperature of 180° C. After cooling, 350 ml H2O are added and the clear, light brown solution adjusted with hydrochloric acid to pH 7.0. The white precipitate is suctioned off, washed with 20 mg H2O and dried in a vacuum drying cabinet at 65° C. The produce is recrystallized twice from water. After cooling washed with 20 mg H2O dried in a vacuum drying cabinet at 65° C The produce is recrystallized twice from water

反应条件: temp:40.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A suspension of 144.1 g (1.5 Mol) ammonium carbonate in 800 ml methanol/water 1:1 mixture is prepared in a 2 liter three-necked flask. At a temperature of 20° C. 43.2 ml (1.1 Mol) hydrocyanic acid are added within 1 minute. 152.8 g (1.0 Mol) 4-phenyl-2-butanol (benzyl acetone) are then added dropwise, leading to a slight exothermic reaction (temperature increase to ca. 30° C.). The white emulsion is maintained at 40° C. for 1 hour and then for 2.5 hours at 60° C. The precipitate is suction filtered, washed twice with 50 ml methanol/H2O 1:1 and dried in a vacuum at 60° C. is prepared in a 2 liter three-necked flask At a temperature of 20° C leading to a slight exothermic reaction (temperature increase to ca. 30° C.) filtered washed twice with 50 ml methanol/H2O 1:1 dried in a vacuum at 60° C.