2-丙-2-基氧基乙酰基 氯化物

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 4.90 g (33 mmol) of methyl anthranilate and 6.1 ml of triethylamine in 50 ml of dichloromethane was dropwise added a solution of 4.43 g (33 mmol) of isopropoxyacetylchloride in 20 ml of dichloromethane under chilling with ice for a period of 15 min. The resulting mixture was stirred over night at room temperature. The reaction mixture was washed sequentially with 5 % aqueous sodium carbonate, 3 N hydrochloric acid and 5% aqueous sodium carbonate, and then was dried over anhydrous sodium sulfate. The solvent was distilled off to leave 5.59 g of the desired compound as a residual pale brown oil. (Yield: 68.6 %) under chilling with ice for a period of 15 min The reaction mixture was washed sequentially with 5 % aqueous sodium carbonate, 3 N hydrochloric acid and 5% aqueous sodium carbonate was dried over anhydrous sodium sulfate The solvent was distilled off