2-溴苄氯

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-bromobenzyl chloride (327 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 400 mg of the product 235. 1H NMR (DMSO-d6) δ 11.52 (s, 2 H), 7.86 (d, 1 H), 7.78 (d, 1 H), 7.55-7.30 (m, 2 H), 7.20-7.00 (m, 6 H), 7.00-6.85 (m, 4 H), 5.83 (s, 2 H), 4.95 (s, 2 H); MS: m/z 424 (M++1). evaporated to dryness The insoluble material is filtered

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-bromobenzyl chloride (327 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 400 mg of the product 235. 1H NMR (DMSO-d6) δ 11.52 (s, 2 H), 7.86 (d, 1 H), 7.78 (d, 1 H), 7.55-7.30 (m, 2 H), 7.20-7.00 (m, 6 H), 7.00-6.85 (m, 4 H), 5.83 (s, 2 H), 4.95 (s, 2 H); MS: m/z 424 (M++1). evaporated to dryness The insoluble material is filtered

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-bromobenzyl chloride (327 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 400 mg of the product 235. 1H NMR (DMSO-d6) δ 11.52 (s, 2H), 7.86 (d, 1H), 7.78 (d, 1H), 7.55-7.30 (m, 2H), 7.20-7.00 (m, 6H), 7.00-6.85 (m, 4H), 5.83 (s, 2H), 4.95 (s, 2H); MS: m/z 424 (M++1). evaporated to dryness The insoluble material is filtered

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-bromobenzyl chloride (327 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 400 mg of the product 235. 1H NMR (DMSO-d6) δ 11.52 (s, 2 H), 7.86 (d, 1 H), 7.78 (d, 1 H), 7.55-7.30 (m, 2 H), 7.20-7.00 (m, 6 H), 7.00-6.85 (m, 4 H), 5.83 (s, 2 H), 4.95 (s, 2 H); MS: m/z 424 (M++1). evaporated to dryness The insoluble material is filtered