喹硫平EP杂质U

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of gaseous HCl in i-PrOH (5.7 g, 31 wt-%) was added dropwise under stirring to a solution of dibenzo[b,f][1,4]thiazepin-11-ylamine (10.6 g) dissolved in a isopropanol/tert-butyl methyl ether (TBME) mixture (150 ml/120 ml). Stirring was continued for 1 h and the formed precipitate was filtered off, washed with tert-butyl methyl ether (TBME) and dried on air to obtain the desired compound as a colorless solid (11.2 g, 91%). the formed precipitate was filtered off washed with tert-butyl methyl ether (TBME) dried on air