甲基 2-(呋喃-2-基)-2-(苯基甲氧基羰基氨基)乙酸甲酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To magnetically stirred 33 wt % hydrogen bromide (2.00 ml, 11.04 mmol) in acetic acid was added methyl 2-(((benzyloxy)carbonyl)amino)-2-(furan-2-yl)acetate (579 mg, 2 mmol). After stirring at room temperature for 1 hr, 25 mL of anhydrous ether was added to give methyl 2-amino-2-(furan-2-yl)acetate hydrobromide (468 mg, 1.983 mmol, 99% yield) as a grey solid. 1H NMR (400 MHz, DMSO-d6) δ 8.93 (s, 2H), 7.81 (dd, J=1.8, 0.8 Hz, 1H), 6.69 (m, 1H), 6.57 (dd, J=3.3, 1.9 Hz, 1H), 5.61 (s, 1H), 3.78 (s, 3H).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To magnetically stirred 33 wt % hydrogen bromide (2.00 ml, 11.04 mmol) in acetic acid was added methyl 2-(((benzyloxy)carbonyl)amino)-2-(furan-2-yl)acetate (579 mg, 2 mmol). After stirring at room temperature for 1 hr, 25 mL of anhydrous ether was added to give methyl 2-amino-2-(furan-2-yl)acetate hydrobromide (468 mg, 1.983 mmol, 99% yield) as a grey solid. 1H NMR (400 MHz, DMSO-d6) δ 8.93 (s, 2H), 7.81 (dd, J=1.8, 0.8 Hz, 1H), 6.69 (m, 1H), 6.57 (dd, J=3.3, 1.9 Hz, 1H), 5.61 (s, 1H), 3.78 (s, 3H).