4-苯基硫基丁-2-one

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 9.01 g (50 mmol) of 4-phenylthio-2-butanone were dissolved in 30 ml of MTBE and treated with 1.0 g of ion exchanger Amberlyst A-21. After this, 9.8 ml (250 mmol) of HCN were added with stirring and the mixture was stirred at room temperature for 2 hours. The ion exchanger was filtered off and 0.05 g of citric acid was added to the solution. The solvent and HCN were stripped off in vacuo at 40° C. on a rotary evaporator. 9.5 g of (R/S)-2-hydroxy-4-phenylthiobutyronitrile (91.7% of theory) were found. the mixture was stirred at room temperature for 2 hours The ion exchanger was filtered off 0.05 g of citric acid was added to the solution The solvent and HCN were stripped off in vacuo at 40° C. on a rotary evaporator