暂无可渲染的结构数据
COC1=CC(=CC(=C1Br)OC)CCl产品信息
2-溴-5-(氯甲基)-1,3-二甲氧基苯（CAS 61367-63-3）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
可能的应用方向
仅供专业研发与工业用途
数据库编号 24971972
安全提示
仅供专业研发与工业用途。操作前请依据供应商提供的安全数据表完成风险评估。
合成路线数据
12 条反应 · 12 篇文献
反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-1b0ffb2326af42dab61eb635488a7476反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-a4e2e807b91f47ac9a5d58bd55a1987d反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-9f1b12116dac45e1a0ff05aa3c136274反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-b604d20cb1fe46868d15abed079b06bb反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-1b0ffb2326af42dab61eb635488a7476反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To an N,N-dimethylformamide (15 ml) solution of 2-propanol (7.81 ml, 102 mmol) was added sodium hydride (4.08 g, 102 mmol) at room temperature, and the mixture was stirred for 30 minutes. To the mixture was added an N,N-dimethylformamide (15 ml) solution of 2-bromo-5-(chloromethyl)-1,3-dimethoxybenzene (2.70 g, 10.2 mmol) and the mixture was stirred for one hour. After the reaction was completed, water was added to the reaction mixture while cooling on ice, which was extracted with ethyl acetate and dried over anhydrous magnesium sulfate, and the solvent was then distilled off under reduced pressure. The residue was purified by silica gel column chromatography (n-heptane/ethyl acetate: 3/1) to obtain the title compound (1.85 g, 6.40 mmol). the mixture was stirred for one hour while cooling on ice, which was extracted with ethyl acetate dried over anhydrous magnesium sulfate the solvent was then distilled off under reduced pressure The residue was purified by silica gel column chromatography (n-heptane/ethyl acetate: 3/1)
来源 ID: ord-b0a3d06e3a164d8787bcb50a31dd6478反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To a mixture of cyclobutyl alcohol (4.16 g, 57.7 mmol) and DMF (30 mL) was added sodium hydride (60% oil dispersion: 2.31 g, 57.7 mmol) while cooling on ice, and the mixture was stirred at room temperature for one hour. To the mixture was gradually added dropwise a mixture of 2-bromo-5-(chloromethyl)-1,3-dimethoxybenzene (2.47 g, 9.3 mmol) and DMF (30 mL), and the mixture was stirred at room temperature for one hour. Water was added to the mixture while cooling on ice, and then ethyl acetate was added. After thoroughly shaking the mixture, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was filtered, and then the solvent in the filtrate was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (a mixed solvent of n-heptane and ethyl acetate: n-heptane/ethyl acetate=4/1) to obtain the title compound (2.39 g, 7.94 mmol). while cooling on ice To the mixture was gradually added dropwise the mixture was stirred at room temperature for one hour while cooling on ice After thoroughly shaking the mixture the organic layer was separated the organic layer was washed with brine dried over anhydrous magnesium sulfate The mixture was filtered the solvent in the filtrate was distilled off under reduced pressure The residue was purified by silica gel column chromatography (a mixed solvent of n-heptane and ethyl acetate
来源 ID: ord-5b659e429b134b459463fc5cd1122af5反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To a mixture of (4-bromo-3,5-dimethoxyphenyl)methanol (10.0 g, 40.6 mmol) and dichloromethane (100 mL) were added triethylamine (12.4 mL, 89.3 mmol) and methanesulfonyl chloride (3.46 mL, 44.7 mmol) in this order while cooling on ice, and the mixture was stirred at room temperature for 14 hours. To the mixture was added water, and then ethyl acetate was added. After thoroughly shaking the mixture, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was filtered, and then the solvent in the filtrate was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (a mixed solvent of n-heptane and ethyl acetate: n-heptane/ethyl acetate=4/1) to obtain the title compound (2.47 g, 9.30 mmol). while cooling on ice After thoroughly shaking the mixture the organic layer was separated the organic layer was washed with brine dried over anhydrous magnesium sulfate The mixture was filtered the solvent in the filtrate was distilled off under reduced pressure The residue was purified by silica gel column chromatography (a mixed solvent of n-heptane and ethyl acetate
来源 ID: ord-9fdee2737a0e4f69bbfa35d7e843adc0反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-a4e2e807b91f47ac9a5d58bd55a1987d反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-9f1b12116dac45e1a0ff05aa3c136274反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To an N,N-dimethylformamide (15 ml) solution of 2-propanol (7.81 ml, 102 mmol) was added sodium hydride (4.08 g, 102 mmol) at room temperature, and the mixture was stirred for 30 minutes. To the mixture was added an N,N-dimethylformamide (15 ml) solution of 2-bromo-5-(chloromethyl)-1,3-dimethoxybenzene (2.70 g, 10.2 mmol) and the mixture was stirred for one hour. After the reaction was completed, water was added to the reaction mixture while cooling on ice, which was extracted with ethyl acetate and dried over anhydrous magnesium sulfate, and the solvent was then distilled off under reduced pressure. The residue was purified by silica gel column chromatography (n-heptane/ethyl acetate: 3/1) to obtain the title compound (1.85 g, 6.40 mmol). the mixture was stirred for one hour while cooling on ice, which was extracted with ethyl acetate dried over anhydrous magnesium sulfate the solvent was then distilled off under reduced pressure The residue was purified by silica gel column chromatography (n-heptane/ethyl acetate: 3/1)
来源 ID: ord-b0a3d06e3a164d8787bcb50a31dd6478反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To a mixture of cyclobutyl alcohol (4.16 g, 57.7 mmol) and DMF (30 mL) was added sodium hydride (60% oil dispersion: 2.31 g, 57.7 mmol) while cooling on ice, and the mixture was stirred at room temperature for one hour. To the mixture was gradually added dropwise a mixture of 2-bromo-5-(chloromethyl)-1,3-dimethoxybenzene (2.47 g, 9.3 mmol) and DMF (30 mL), and the mixture was stirred at room temperature for one hour. Water was added to the mixture while cooling on ice, and then ethyl acetate was added. After thoroughly shaking the mixture, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was filtered, and then the solvent in the filtrate was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (a mixed solvent of n-heptane and ethyl acetate: n-heptane/ethyl acetate=4/1) to obtain the title compound (2.39 g, 7.94 mmol). while cooling on ice To the mixture was gradually added dropwise the mixture was stirred at room temperature for one hour while cooling on ice After thoroughly shaking the mixture the organic layer was separated the organic layer was washed with brine dried over anhydrous magnesium sulfate The mixture was filtered the solvent in the filtrate was distilled off under reduced pressure The residue was purified by silica gel column chromatography (a mixed solvent of n-heptane and ethyl acetate
来源 ID: ord-5b659e429b134b459463fc5cd1122af5PubChem References
以下资料来自该化合物的公开数据库参考记录。