2-十二烷酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 3-([1,1′-biphenyl]-4yl)-2-butenol (4e, 200 mg) and methylene blue (2 mg) in acetonitrile (10 ml) and chloroform (10 ml) was photooxygenated at 0° C. for 3 h. 2-dodecanone (0.5 ml) and hydrochloric acid (2 drops) were added and reaction mixture of left at r.t. for 18 h. The reaction mixture was worked up and concentrated. Crude product was purified by column chromatography on silica gel to furnish 100 mg mg (27% yield, based on allylic alcohol, 4e, used) of trioxane 7ed m.p. 86-90° C. reaction mixture concentrated Crude product was purified by column chromatography on silica gel to furnish 100 mg mg (27% yield

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2-dodecanone is prepared from 1-dodecene according to the process of the present invention as follows: A catalyst solution is prepared by dissolving .04 moles of palladium chloride in a mixture of 137 grams of methanol, 252 grams of polypropylene glycol having an average molecular weight of 430, and 15 grams of water. The catalyst solution is then charged to a 2 liter titanium autoclave where the catalyst solution is heated to a temperature of 60°C; while being stirred at 1,000 r.p.m. with the reactor being pressurized to 100 p.s.i.g. with oxygen. Using a piston pump, 600 grams of 1-dodecene is introduced to the autoclave over a period of 21/2 hours. During this period of addition, the reaction temperature is maintained at 60°C by cooling, with the reaction pressure of 100 p.s.i.g. being maintained by repressuration with oxygen. Stirring is continued for about 1/2 hour after the addition of 1-dodecene is completed. A catalyst solution is prepared During this period of addition the reaction temperature is maintained at 60°C Stirring