4-(4-氟苯基)丁烷-2-酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 4-(4-Fluorophenyl)-2-butanone (10.0 g) in ether (30 ml) was added over 20 min. to a stirred solution of methyl magnesium iodide (0.086 mole) in ether (80 ml). The mixture was stirred at room temperature over 5 hr, then cooled and 2 M sulphuric acid (30 ml) added. The mixture was extracted with ether (5×50 ml), washed with saturated sodium bicarbonate solution, saturated brine and dried (MgSO4). The solvent was removed and the residue was distilled. The alcohol (9.4 g) b.p. 83°-85°/0.1 mm was obtained as a colourless liquid. cooled The mixture was extracted with ether (5×50 ml) washed with saturated sodium bicarbonate solution, saturated brine dried (MgSO4) The solvent was removed the residue was distilled

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 4-(4-Fluorophenyl)-2-butanone (10.0 g) in ether (30 ml) was added over 20 min. to a stirred solution of methyl magnesium iodide (0.086 mole) in ether (80 ml). The mixture was stirred at room temperature over 5 hr, then cooled and 2 M sulphuric acid (30 ml) added. The mixture was extracted with ether (5×50 ml), washed with saturated sodium bicarbonate solution, saturated brine and dried (MgSO4). The solvent was removed and the residue was distilled. The alcohol (9.4 g) b.p. 83°-85°/0.1 mm was obtained as a colourless liquid. cooled The mixture was extracted with ether (5×50 ml) washed with saturated sodium bicarbonate solution, saturated brine dried (MgSO4) The solvent was removed the residue was distilled