4-(4-氟苯基)丁-2-胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2.6 g (0.015 mol) of 2-amino-4-chloro-6-isopropyl-1,3,5-triazine and 2.1 g (0.015 mol) of K2CO3 are initially introduced in 50 ml of acetonitrile. 2.5 g (0.015 mol) of 1-(4-fluorophenyl)-3-butylamine, dissolved in 20 ml of acetonitrile, are added dropwise to this solution. It is then heated to reflux for 3 hours. The solid constituents are then filtered off with suction and the filtrate is concentrated in a rotary evaporator. The residue is purified by means of column chromatography (eluent: ethyl acetate). Yield: 4.1 g (90% of theory). are added dropwise to this solution It is then heated to reflux for 3 hours The solid constituents are then filtered off with suction the filtrate is concentrated in a rotary evaporator The residue is purified by means of column chromatography (eluent: ethyl acetate)