(2-ethoxyphenoxy)acetonitrile

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Potassium carbonate (550 g, 3.98 mol) was added to acetone (1800 ml) and resulting suspension was stirred for 30 min. 2-Ethoxyphenol (460 g, 3.329 mol) was gradually added under stirring. The mixture was heated to reflux. Chloroacetonitrile (275 g, 3.642 mol) was added and the mixture was stirred under reflux for 24 hours. The reaction mixture was cooled down to room temperature. Solid was filtered off, washed with acetone (750 ml) and combined filtrates were evaporated to give oil. The oil was dissolved in ethanol (180 ml), the solution was heated to reflux and mixture of water (530 ml) and aqueous ammonia (45 ml) was added. The mixture was cooled to 5-10° C. under stirring. Crude crystalline product was filtered, washed with mixture of ethanol (250 ml) and water (400 ml). The crude product was recrystallized from ethanol /water mixture to give pure product (500 g). resulting suspension under stirring The mixture was heated to reflux the mixture was stirred under reflux for 24 hours Solid was filtered off washed with acetone (750 ml) were evaporated to give oil the solution was heated to reflux was added The mixture was cooled to 5-10° C. under stirring Crude crystalline product was filtered washed with mixture of ethanol (250 ml) and water (400 ml) The crude product was recrystallized from ethanol /water mixture

反应条件: temp:0.00; pressure:0.00; stir: