1,3,4,6-四-O-乙酰基-2-叠氮基-2-脱氧-A-D-吡喃半乳糖

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 1 ,3,4,6- Tetra-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranose (14) (500 mg) was dissolved in 50 mL CH2Cl2 (anhydrous), treated with 50 mL of CH2Cl2 saturated with HBr at 0° C., and stirred for two hours. Then 2 g of tetraethyl ammonium bromide was added and stirred overnight. Next, the solution was washed with 100 mL ice-cold water and concentrated. The residue was crystallized from ethyl ether and pentane to give 400 mg of 3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranosyl bromide (18). stirred overnight Next, the solution was washed with 100 mL ice-cold water concentrated The residue was crystallized from ethyl ether and pentane