N-丁基哌啶-3-甲酰胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: N-n-Butylnicotinamide (7.0 g) in acetic acid (100 ml) was hydrogenated over platinum oxide at 50° and 50 p.s.i. The catalyst was removed by filtration, the filtrate evaporated and the residue treated with toluene and evaporated in vacuo. The residue in chloroform (50 ml) was washed with sodium bicarbonate solution (3×50 ml) the organic layer separated, dried (Na2SO4) and the solvent evaporated in vacuo to give as an oil 3-(N-n-butylcarbamoyl)piperidine (3.8 g). The catalyst was removed by filtration the filtrate evaporated the residue treated with toluene evaporated in vacuo The residue in chloroform (50 ml) was washed with sodium bicarbonate solution (3×50 ml) the organic layer separated dried (Na2SO4) the solvent evaporated in vacuo