3-[2-(三氟甲基)苯氧基]氮杂环丁烷

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The compound was prepared from 3-[2-(trifluoromethyl)phenoxy]azetidine and methylisocyanate as described in Example 5 of U.S. Pat. No. 4,226,861, m.p. 134°-136° C.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a stirring solution of 3-(2-trifluoromethylphenoxy) azetidine (4.5 g., 0.02 mole) in 50 ml. of dry benzene was added slowly at room temperature 1.2 g. (0.02 mole) of methylisocyanate. After an additional 30 minutes a solid separated which was collected and recrystallized from benzene. The product (3.5 g., 68%) melted at 134°-136° C. After an additional 30 minutes a solid separated which was collected recrystallized from benzene

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To 4.5 g (0.02 mole) of 3-[2-(trifluoromethyl)phenoxy]azetidine stirring in 50 ml of dry benzene, was added slowly 1.2 g (0.02 mole) of methyl isocyanate at room temperature. Stirring was continued for 30 minutes. A solid formed, and after filtration was recrystallized from benzene to yield 3.5 g (68%), mp 134°-136°. A solid formed after filtration was recrystallized from benzene to yield 3.5 g (68%), mp 134°-136°

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The compound was prepared from 3-[2-(trifluoromethyl)phenoxy)azetidine and methylisocyanate as described in Example 5 of U.S. Pat. No. 4,226,861, m.p. 134°-136° C.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The compound was prepared from 3-[2-(trifluoromethyl)phenoxy]azetidine and methylisocyanate as described in Example 5 of U.S. Pat. No. 4,226,861, m.p. 134°-136° C.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The compound was prepared from 3-[2-(trifluoromethyl)phenoxy]azetidine and methylisocyanate as described in Example 5 of U.S. Pat. No. 4,226,861, m.p. 134°-136° C.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a stirring solution of 3-(2-trifluoromethylphenoxy) azetidine (4.5 g., 0.02 mole) in 50 ml. of dry benzene was added slowly at room temperature 1.2 g. (0.02 mole) of methylisocyanate. After an additional 30 minutes a solid separated which was collected and recrystallized from benzene. The product (3.5 g., 68%) melted at 134°-136° C. After an additional 30 minutes a solid separated which was collected recrystallized from benzene