甲基 2-(4-羟基苯基)-2-甲氧基乙酸酯

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 2-methoxy-2-(4-hydroxyphenyl)acetic acid methyl ester (see Example 10) (8g; 40 mmol), potassium carbonate (11.04 g; 80 mmol) and 2-chloromethylpyridine hydrochloride (6.56 g; 40 mmol) in DMF (150 ml) was stirred at room temperature for 16 h, and then poured into icy water. The product was extracted with ethyl acetate, the acetate layer was washed with water, brine, dried with magnesium sulfate ans concentated in vacuo. The residue was purified by column chromatography (hexane-ethyl acetate 3:1) to afford 2.0 g of 2-methoxy-2-[4-(2-pyridylmethoxy)phenyl]acetic acid methyl ester. The product was extracted with ethyl acetate the acetate layer was washed with water, brine dried with magnesium sulfate ans The residue was purified by column chromatography (hexane-ethyl acetate 3:1)