N-苄基-N-甲基戊聚糖-1-胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: N-methylbenzylamine (50 g, 0.41 moles), acetone (100 ml) and potassium carbonate 57 g (0.41 moles) were mixed at room temperature and to the slurry obtained, 1-bromopentane 105.7 g (0.7 moles) was added dropwise at the room temperature. Reaction mixture was then stirred at room temperature for 18 hrs. The reaction mixture was filtered, washed with acetone and concentrated under vacuum to an oily residue. The residue was dissolved in 100 ml of MDC and washed with water (3×50 ml). Organic layer was dried over sodium sulphate and concentrated under vacuum to get N-methyl N-pentyl benzylamine as an oil. (Yield=77 g, 98%). obtained Reaction mixture The reaction mixture was filtered washed with acetone concentrated under vacuum to an oily residue The residue was dissolved in 100 ml of MDC washed with water (3×50 ml) Organic layer was dried over sodium sulphate concentrated under vacuum

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: N-methylbenzylamine 100 gms (0.82 moles), acetone (200 ml) and potassium carbonate 114 gms (0.82 moles) were mixed at room temperature and to the slurry obtained, 1-bromopentane 211.4 gms (1.4 moles) was added dropwise at room temperature. Reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was filtered, washed with acetone and concentrated under vacuum to an oily residue. The residue was dissolved in MDC (200 ml) and washed with water (3×100 ml). Organic layer was dried over sodium sulphate and concentrated under vacuum to get 154 gms of the title compound as an oil. obtained Reaction mixture The reaction mixture was filtered washed with acetone concentrated under vacuum to an oily residue The residue was dissolved in MDC (200 ml) washed with water (3×100 ml) Organic layer was dried over sodium sulphate concentrated under vacuum

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The present invention provides an alternate process for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III) wherein N-methyl benzyl amine is condensed with 1-bromo pentane in presence of potassium carbonate, using acetone as solvent to give N-methyl N-pentyl benzyl amine. This is debenzylated using palladium on carbon as catalyst and alcohol as solvent. The resulting product N-methyl pentyl amine is condensed with methyl acrylate in toluene to get 3-[N-(methylpentyl)amino]propionate, which is further hydrolysed to obtain Intermediate III. The present invention provides an alternate process