(1R,3S)-1-(BOC-氨基)-3-氨基环戊烷

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following the procedure for ((1R,3R)-3-amino-cyclopentyl)-carbamic acid tert-butyl ester the title compound was prepared from ((1R,3S)-3-allyloxycarbonylamino-cyclopentyl)-carbamic acid tert-butyl ester with further purification by column chromatography on silica gel (gradient: 0 to 5% methanol in DCM then 0 to 10% 2M NH3 in methanol solution in DCM) to afford 300 mg (56%) of ((1R,3S)-3-amino-cyclopentyl)-carbamic acid tert-butyl ester. LCMS (Method I, ESI): RT=0.32 min, m+H-Boc=101.2; 1H NMR (400 MHz, DMSO) δ: 6.84 (s, 1H), 3.77-3.69 (m, 1H), 3.21 (m, 2H), 2.00 (m, 1H), 1.78-1.63 (m, 2H), 1.50 (m, 1H), 1.37 (s, 9H), 1.17 (m, 1H).