反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: The title compound is prepared starting from 2-cyclopentyl-6-methoxy-isonicotinic acid, 3-chloro-4-(2,2-dimethoxyethoxy)-N-hydroxy-5-methoxybenzimidamide and ethyl azetid ine-3-carboxylate in analogy to Example 43 and 1 (saponification); LC-MS: tR=0.88 min, [M+H]+=528.92; 1H NMR (CDCl3): δ 7.79 (d, J=1.5 Hz, 1H), 7.57 (d, J=1.4 Hz, 1H), 7.45 (s, 1H), 7.24 (s, 1H), 5.96 (s br, 1H), 4.55-4.64 (m, 2H), 4.44-4.54 (m, 2H), 4.32-4.38 (m, 2H), 4.00 (s, 6H), 3.65-3.74 (m, 1H), 3.58-3.65 (m, 2H), 3.18-3.27 (m, 1H), 2.05-2.14 (m, 2H), 1.82-1.94 (m, 4H), 1.75 (m, 2H).
来源 ID: ord-d18d771baff34523af4206453964acdb