(R)-4-苯基-3-哌啶-4-基-恶唑烷-2-酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Using general procedure B with the above amine (101 mg, 0.41 mmol) and 2-(3-oxo-butyl)-isoindole-1,3-dione (179 mg, 0.82 mmol) followed by general procedure D gave (R)-3-[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-4-phenyl-oxazolidin-2-one (81 mg, 62% over 2 steps).