TERT-BUTYL [(4S)-4-AMINO-5-HYDROXYPENTYL]CARBAMATE

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 169 mg (0.48 mmol) of benzyl [(1S)-4-[(tert -butoxycarbonyl)amino]-1-(hydroxymethyl)butyl]carbamate (Example Z4) in 50 ml of ethanol is hydrogenated after the addition of 17 mg of palladium on activated carbon (10%) under atmospheric pressure at RT for 4 h. The mixture is filtered through kieselguhr, and the residue is washed with ethanol. The filtrate is evaporated to dryness in vacuo. The product is reacted without further purification. The mixture is filtered through kieselguhr the residue is washed with ethanol The filtrate is evaporated to dryness in vacuo The product is reacted without further purification