N-(2-甲氧基乙基)-2-哌嗪-1-基-乙酰胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and 2-methoxyethylamine in an analogous manner as described in example 21.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with N-(2-methoxy-ethyl)-2-piperazin-1-yl-acetamide (Enamine) to give the title compound. HR-MS (ES, m/z) calculated for C38H49Cl2N6O4 [(M+H)+] 723.3187, observed 723.3191.