甲基 (2R)-2-氨基-3-[(2-甲基丙-2-基)氧基]丙酸甲酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 330.0 L of methanol was added and 66.0 kg of (R)-methyl 2-(benzyloxycarbonylamino)-3-t-butoxypropanoate was added to a hydrogen reactor; and then purged with nitrogen. 4.95 kg of palladium/carbon (10% water mixture) was added and hydrogen was filled to maintain at 5 bar of pressure. It was stirred for 60 minutes, filtered, washed, and then concentrated under reduced pressure. 132.0 L of ethyl acetate and 88 L of water were added to a concentrated residue; stirred for 10 minutes; an organic layer was isolated (in 6 times), dehydrated, and then concentrated under reduced pressure to obtain 27.5 kg of a title compound. and then purged with nitrogen 4.95 kg of palladium/carbon (10% water mixture) was added hydrogen was filled to maintain at 5 bar of pressure filtered washed concentrated under reduced pressure 132.0 L of ethyl acetate and 88 L of water were added to a concentrated residue stirred for 10 minutes an organic layer was isolated (in 6 times) concentrated under reduced pressure