1-[1-(甲氧基甲基)环丙基]甲胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (1-(methoxymethyl)cyclopropyl)methanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 0.36-0.44 (m, 2 H) 0.52-0.60 (m, 2 H) 2.43 (s, 3 H) 3.22-3.28 (m, 5 H) 3.35 (s, 2 H) 7.66 (d, J=7.83 Hz, 1 H) 7.73 (s, 1 H) 7.77 (br. s., 1 H) 8.08-8.26 (m, 1 H) 8.42 (d, J=6.57 Hz, 2 H) 8.64 (t, J=5.56 Hz, 1 H) 8.88-8.94 (m, 1 H) 12.96-13.46 (m, 1 H). MS m/z [M+H]+ 418.2

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (1-(methoxymethyl)cyclopropyl)methanamine. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.36-0.44 (m, 2H) 0.52-0.60 (m, 2H) 2.43 (s, 3H) 3.22-3.28 (m, 5H) 3.35 (s, 2H) 7.66 (d, J=7.83 Hz, 1H) 7.73 (s, 1H) 7.77 (br. s., 1H) 8.08-8.26 (m, 1H) 8.42 (d, J=6.57 Hz, 2H) 8.64 (t, J=5.56 Hz, 1H) 8.88-8.94 (m, 1H) 12.96-13.46 (m, 1H). MS m/z [M+H]+ 418.2

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (1-(methoxymethyl)cyclopropyl)methanamine. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.36-0.44 (m, 2H) 0.52-0.60 (m, 2H) 2.43 (s, 3H) 3.22-3.28 (m, 5H) 3.35 (s, 2H) 7.66 (d, J=7.83 Hz, 1H) 7.73 (s, 1H) 7.77 (br. s., 1H) 8.08-8.26 (m, 1H) 8.42 (d, J=6.57 Hz, 2H) 8.64 (t, J=5.56 Hz, 1H) 8.88-8.94 (m, 1H) 12.96-13.46 (m, 1H). MS m/z [M+H]+ 418.2

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (1-(methoxymethyl)cyclopropyl)methanamine 1H NMR (400 MHz, DMSO-d6) δ ppm 0.36-0.44 (m, 2 H) 0.52-0.60 (m, 2 H) 2.43 (s, 3 H) 3.22-3.28 (m, 5 H) 3.35 (s, 2 H) 7.66 (d, J=7.83 Hz, 1 H) 7.73 (s, 1 H) 7.77 (br. s., 1 H) 8.08-8.26 (m, 1 H) 8.42 (d, J=6.57 Hz, 2 H) 8.64 (t, J=5.56 Hz, 1 H) 8.88-8.94 (m, 1 H) 12.96-13.46 (m, 1 H). MS m/z [M+H]+ 418.2

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (1-(methoxymethyl)cyclopropyl)methanamine. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.36-0.44 (m, 2H) 0.52-0.60 (m, 2H) 2.43 (s, 3H) 3.22-3.28 (m, 5H) 3.35 (s, 2H) 7.66 (d, J=7.83 Hz, 1H) 7.73 (s, 1H) 7.77 (br. s., 1H) 8.08-8.26 (m, 1H) 8.42 (d, J=6.57 Hz, 2H) 8.64 (t, J=5.56 Hz, 1H) 8.88-8.94 (m, 1H) 12.96-13.46 (m, 1H). MS m/z [M+H]+ 418.2