15-溴十五酸叔丁酯

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-Hydroxy-isophthalic acid dimethyl ester (420 mg, 2 mmol), 15-bromo-pentadecanoic acid tert-butyl ester (755 mg, 2 mmol) and K2CO3 (415 mg, 3 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed by TLC (4:1 heptane/AcOEt), which indicated reaction completion after 6 h. The sample was concentrated to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield a white crystalline solid (1.0 g, 100%). refluxed under N2 reaction completion after 6 h The sample was concentrated AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15-Bromo-pentadecanoic acid tert-butyl ester (598 mg, 1.59 mmol), 4-hydroxy isophthalic acid 3-tert-butyl ester 1-methyl ester (400 mg, 1.59 mmol) and K2CO3 (329 mg, 2.38 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed via TLC (4:1 heptane/AcOEt). After 13 h the sample was concentrated under vacuum to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield an oil (841 mg, 97%). refluxed under N2 After 13 h the sample was concentrated under vacuum AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15-Bromo-pentadecanoic acid tert-butyl ester (598 mg, 1.59 mmol), 4-hydroxy isophthalic acid 3-tert-butyl ester 1-methyl ester (400 mg, 1.59 mmol) and K2CO3 (329 mg, 2.38 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed via TLC (4:1 heptane/AcOEt). After 13 h the sample was concentrated under vacuum to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield an oil (841 mg, 97%). refluxed under N2 After 13 h the sample was concentrated under vacuum AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-Hydroxy-isophthalic acid dimethyl ester (420 mg, 2 mmol), 15-bromo-pentadecanoic acid tert-butyl ester (755 mg, 2 mmol) and K2CO3 (415 mg, 3 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed by TLC (4:1 heptane/AcOEt), which indicated reaction completion after 6 h. The sample was concentrated to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield a white crystalline solid (1.0 g, 100%). refluxed under N2 reaction completion after 6 h The sample was concentrated AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15-Bromo-pentadecanoic acid tert-butyl ester (598 mg, 1.59 mmol), 4-hydroxy isophthalic acid 3-tert-butyl ester 1-methyl ester (400 mg, 1.59 mmol) and K2CO3 (329 mg, 2.38 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed via TLC (4:1 heptane/AcOEt). After 13 h the sample was concentrated under vacuum to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield an oil (841 mg, 97%). refluxed under N2 After 13 h the sample was concentrated under vacuum AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-Hydroxy-isophthalic acid dimethyl ester (420 mg, 2 mmol), 15-bromo-pentadecanoic acid tert-butyl ester (755 mg, 2 mmol) and K2CO3 (415 mg, 3 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed by TLC (4:1 heptane/AcOEt), which indicated reaction completion after 6 h. The sample was concentrated to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield a white crystalline solid (1.0 g, 100%). refluxed under N2 reaction completion after 6 h The sample was concentrated AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15-Bromo-pentadecanoic acid tert-butyl ester (598 mg, 1.59 mmol), 4-hydroxy isophthalic acid 3-tert-butyl ester 1-methyl ester (400 mg, 1.59 mmol) and K2CO3 (329 mg, 2.38 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed via TLC (4:1 heptane/AcOEt). After 13 h the sample was concentrated under vacuum to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield an oil (841 mg, 97%). refluxed under N2 After 13 h the sample was concentrated under vacuum AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-Hydroxy-isophthalic acid dimethyl ester (420 mg, 2 mmol), 15-bromo-pentadecanoic acid tert-butyl ester (755 mg, 2 mmol) and K2CO3 (415 mg, 3 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed by TLC (4:1 heptane/AcOEt), which indicated reaction completion after 6 h. The sample was concentrated to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield a white crystalline solid (1.0 g, 100%). refluxed under N2 reaction completion after 6 h The sample was concentrated AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15-Bromo-pentadecanoic acid tert-butyl ester (598 mg, 1.59 mmol), 4-hydroxy isophthalic acid 3-tert-butyl ester 1-methyl ester (400 mg, 1.59 mmol) and K2CO3 (329 mg, 2.38 mmol) were placed in a flask with acetonitrile (25 ml) and refluxed under N2. The reaction was followed via TLC (4:1 heptane/AcOEt). After 13 h the sample was concentrated under vacuum to near dryness. AcOEt (50 ml) and water (25 ml) were added to the residue. The phases were separated and the organic phase was washed with water and brine (25 ml each), dried over MgSO4 and concentrated to yield an oil (841 mg, 97%). refluxed under N2 After 13 h the sample was concentrated under vacuum AcOEt (50 ml) and water (25 ml) were added to the residue The phases were separated the organic phase was washed with water and brine (25 ml each) dried over MgSO4 concentrated