N-(4-bromobenzyl)formamide

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Into a mixture of 9.87 g of 4-bromobenzylamine hydrochloride and 5.04 g of triethylamine, 20 mL of a formic acid solution was dropped and the resultant reaction mixture was stirred at 80° C. for 3.5 hours. After the completion of the reaction, the reaction mixture was charged into 100 mL of ice water and the resultant reaction mixture was extracted with ethyl acetate (30 mL×2). The organic phase was dehydrated and dried over a saturated brine and anhydrous sodium sulfate in this order and the solvent was distilled off under reduced pressure. The residual solid was washed with hexane to obtain 9.29 g of the objective substance as a white crystal. was dropped the resultant reaction mixture After the completion of the reaction the resultant reaction mixture was extracted with ethyl acetate (30 mL×2) dried over a saturated brine and anhydrous sodium sulfate in this order the solvent was distilled off under reduced pressure The residual solid was washed with hexane to obtain 9.29 g of the objective substance as a white crystal

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Into a mixture of 9.87 g of 4-bromobenzylamine hydrochloride and 5.04 g of triethylamine, 20 mL of a formic acid solution was dropped and the resultant reaction mixture was stirred at 80° C. for 3.5 hours. After the completion of the reaction, the reaction mixture was charged into 100 mL of ice water and the resultant reaction mixture was extracted with ethyl acetate (30 mL×2). The organic phase was dehydrated and dried over a saturated brine and anhydrous sodium sulfate in this order and the solvent was distilled off under reduced pressure. The residual solid was washed with hexane to obtain 9.29 g of the objective substance as a white crystal. was dropped the resultant reaction mixture After the completion of the reaction the resultant reaction mixture was extracted with ethyl acetate (30 mL×2) dried over a saturated brine and anhydrous sodium sulfate in this order the solvent was distilled off under reduced pressure The residual solid was washed with hexane to obtain 9.29 g of the objective substance as a white crystal