8-BOC-1,8-二氮杂螺[4.5]癸烷

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 5 g)) was reacted with tert-butyl 1,8-diazaspiro[4.5]decane-8-carboxylate (937729-06-1) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=494.6 [MH+].

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 5 g)) was reacted with tert-butyl 1,8-diazaspiro[4.5]decane-8-carboxylate (937729-06-1) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=494.6 [MH+].