3-氟-4-(2-甲氧基乙氧基)苯甲醛

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Similar procedure as described in example 343a was used, starting from 3-Fluoro-4-(2-methoxy-ethoxy)-benzaldehyde and malonic acid to give 3-[3-Fluoro-4-(2-methoxy-ethoxy)-phenyl]-acrylic acid. LC-MS: m/e 241 (MH+).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: NaH (7.3 g) was carefully added to a solution of 2-Methoxy-ethanol (15 ml) in DMF (200 ml) and the solution was stirred for 4 hours. 3,4-difluoro-benzaldehyde (14 g) was added to the mixture under N2 at 0° C., and the resulting mixture was slowly warmed to room temperature and stirred for another 6 hours. Saturated aqueous NH4Cl (200 ml) was added to the solution, and the mixture was extracted by ethyl acetate (500 ml×3). The organic layer was evaporated to give 3-Fluoro-4-(2-methoxy-ethoxy)-benzaldehyde as oil (15 g). LC-MS: m/e 199 (MH+). stirred for another 6 hours the mixture was extracted by ethyl acetate (500 ml×3) The organic layer was evaporated