O-(tert-Butyldimethylsilyl)-L-serine Methyl Ester

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: L-Serine methyl ester hydrochloride (7.09 g) was suspended in dichloromethane (100 mL), and to the suspension 4-(dimethylamino)pyridine (700 mg) and triethylamine (9.69 g) were added, and tert-butyldimethylchlorosilane (7.0 g) were added portionwise at 0° C. to the mixture to conduct stirring at room temperature. The reaction mixture was washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform:methanol=20:1) to obtain the title compound. The reaction mixture was washed with water and saturated brine dried over anhydrous sodium sulfate concentrated under reduced pressure The residue was purified by column chromatography on silica gel (chloroform:methanol=20:1)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: L-Serine methyl ester hydrochloride (7.09 g) was suspended in dichloromethane (100 mL), and to the suspension 4-(dimethylamino)pyridine (700 mg) and triethylamine (9.69 g) were added, and tert-butyldimethylchlorosilane (7.0 g) were added portionwise at 0° C. to the mixture to conduct stirring at room temperature. The reaction mixture was washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform:methanol=20:1) to obtain the title compound. The reaction mixture was washed with water and saturated brine dried over anhydrous sodium sulfate concentrated under reduced pressure The residue was purified by column chromatography on silica gel (chloroform:methanol=20:1)