4-氯-1-苯基戊烷-3-one

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In two multi-injection microreactors having 4 reaction regions (each comprising one injection point, one mixing zone and one reaction zone of 1.08 mL internal reaction volume), 2-chloro propionic chloride (13.5 wt %) in tetrahydrofuran (THF, 86.5 wt %) as flow A and phenethyl-magnesium bromide (1 eq., 10 wt %) in THF (1 eq., 90 wt %) as flow B were reacted. Micro-reactor MR1 comprised internal heat exchange structures and provided a very efficient cooling (VEC) while temperature adjustment of metal microreactor MR2 was performed by submersing the microreactor in a temperature adjusted bath and provided only a low efficient cooling (LEC) between the injection points. The temperatures were displayed in table 3. Total flow rates of 20 and 40 g/min after last injection were performed. The 2nd reactant (flow B) is fed to the first reactant in a proportion corresponding to the number of inlet points. About 25 mol-% of flow B necessary to reach completion of the reaction respectively were fed at each inlet point to the first flow. After the last injection the reagents of flow B and flow A were fed in equimolar amount. The yields of the product 4-chloro-1-phenyl-pentan-3-one being collected after the respective reaction zone and quenched are shown in table 2 in relation to feed rate and cooling conditions. 4 reaction regions ( were reacted Micro-reactor MR1 comprised internal heat exchange structures and provided a very efficient cooling (VEC) while temperature adjustment of metal microreactor MR2 provided only a low efficient cooling (LEC) between the injection points The 2nd reactant (flow B) is fed to the first reactant in a proportion corresponding to the number of inlet completion of the reaction respectively were fed at each inlet

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In two multi-injection microreactors having 4 reaction regions (each comprising one injection point, one mixing zone and one reaction zone of 1.08 mL internal reaction volume), 2-chloro propionic chloride (13.5 wt %) in tetrahydrofuran (THF, 86.5 wt %) as flow A and phenethyl-magnesium bromide (1 eq., 10 wt %) in THF (1 eq., 90 wt %) as flow B were reacted. Micro-reactor MR1 comprised internal heat exchange structures and provided a very efficient cooling (VEC) while temperature adjustment of metal microreactor MR2 was performed by submersing the microreactor in a temperature adjusted bath and provided only a low efficient cooling (LEC) between the injection points. The temperatures were displayed in table 3. Total flow rates of 20 and 40 g/min after last injection were performed. The 2nd reactant (flow B) is fed to the first reactant in a proportion corresponding to the number of inlet points. About 25 mol-% of flow B necessary to reach completion of the reaction respectively were fed at each inlet point to the first flow. After the last injection the reagents of flow B and flow A were fed in equimolar amount. The yields of the product 4-chloro-1-phenyl-pentan-3-one being collected after the respective reaction zone and quenched are shown in table 2 in relation to feed rate and cooling conditions. 4 reaction regions ( were reacted Micro-reactor MR1 comprised internal heat exchange structures and provided a very efficient cooling (VEC) while temperature adjustment of metal microreactor MR2 provided only a low efficient cooling (LEC) between the injection points The 2nd reactant (flow B) is fed to the first reactant in a proportion corresponding to the number of inlet completion of the reaction respectively were fed at each inlet

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In two self assembled multi-injection microreactors having 2 to 6 reaction regions assembled from separate injection points, mixing zones and reaction zones (each reaction comprising one injection point, one mixing zone and one reaction zone), 2-chloro propionic chloride (13.5 wt %) in tetrahydrofuran (THF, 86.5 wt %) as flow A and phenethylmagnesium bromide (1 eq., 10 wt %) in THF (1 eq., 90 wt %) as flow B were reacted. The microreactors were placed in a bath at 20° C. Temperature adjustment of the microreactors depended on heat exchange on the outer surface of the single parts of the modules. The microreactor of examples 1.1 to 1.5 comprised reaction zones of about 0.2 mL internal volume allowing almost no cooling between the injection points. The microreactor of examples 1.6 to 1.10 comprised reaction zones of about 2.0 mL internal volume allowing at least a low effective cooling (LEC) between the injection points. Flow rates of 20 and 40 g/min were performed. The 2nd reactant was fed to the 1st reactant in equimolar ratio. The yields of the product 4-chloro-1-phenyl-pentan-3-one collected after the respective reaction zone are shown in table 1 and 2 in relation to feed rate and cooling conditions. to 6 reaction regions from separate injection points mixing zones and reaction zones (each reaction were reacted The microreactors were placed in a bath at 20° C on heat exchange on the outer surface of the single parts of the modules The microreactor of examples 1.1 to 1.5 comprised reaction zones of about 0.2 mL internal volume reaction zones of about 2.0 mL internal volume effective cooling (LEC) between the injection points

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In two multi-injection microreactors having 4 reaction regions (each comprising one injection point, one mixing zone and one reaction zone of 1.08 mL internal reaction volume), 2-chloro propionic chloride (13.5 wt %) in tetrahydrofuran (THF, 86.5 wt %) as flow A and phenethyl-magnesium bromide (1 eq., 10 wt %) in THF (1 eq., 90 wt %) as flow B were reacted. Micro-reactor MR1 comprised internal heat exchange structures and provided a very efficient cooling (VEC) while temperature adjustment of metal microreactor MR2 was performed by submersing the microreactor in a temperature adjusted bath and provided only a low efficient cooling (LEC) between the injection points. The temperatures were displayed in table 3. Total flow rates of 20 and 40 g/min after last injection were performed. The 2nd reactant (flow B) is fed to the first reactant in a proportion corresponding to the number of inlet points. About 25 mol-% of flow B necessary to reach completion of the reaction respectively were fed at each inlet point to the first flow. After the last injection the reagents of flow B and flow A were fed in equimolar amount. The yields of the product 4-chloro-1-phenyl-pentan-3-one being collected after the respective reaction zone and quenched are shown in table 2 in relation to feed rate and cooling conditions. 4 reaction regions ( were reacted Micro-reactor MR1 comprised internal heat exchange structures and provided a very efficient cooling (VEC) while temperature adjustment of metal microreactor MR2 provided only a low efficient cooling (LEC) between the injection points The 2nd reactant (flow B) is fed to the first reactant in a proportion corresponding to the number of inlet completion of the reaction respectively were fed at each inlet

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In two self assembled multi-injection microreactors having 2 to 6 reaction regions assembled from separate injection points, mixing zones and reaction zones (each reaction comprising one injection point, one mixing zone and one reaction zone), 2-chloro propionic chloride (13.5 wt %) in tetrahydrofuran (THF, 86.5 wt %) as flow A and phenethylmagnesium bromide (1 eq., 10 wt %) in THF (1 eq., 90 wt %) as flow B were reacted. The microreactors were placed in a bath at 20° C. Temperature adjustment of the microreactors depended on heat exchange on the outer surface of the single parts of the modules. The microreactor of examples 1.1 to 1.5 comprised reaction zones of about 0.2 mL internal volume allowing almost no cooling between the injection points. The microreactor of examples 1.6 to 1.10 comprised reaction zones of about 2.0 mL internal volume allowing at least a low effective cooling (LEC) between the injection points. Flow rates of 20 and 40 g/min were performed. The 2nd reactant was fed to the 1st reactant in equimolar ratio. The yields of the product 4-chloro-1-phenyl-pentan-3-one collected after the respective reaction zone are shown in table 1 and 2 in relation to feed rate and cooling conditions. to 6 reaction regions from separate injection points mixing zones and reaction zones (each reaction were reacted The microreactors were placed in a bath at 20° C on heat exchange on the outer surface of the single parts of the modules The microreactor of examples 1.1 to 1.5 comprised reaction zones of about 0.2 mL internal volume reaction zones of about 2.0 mL internal volume effective cooling (LEC) between the injection points