反应 #1879754
相关文献 (1)
openreactiondata ↗doi:10.6084/m9.figshare.5104873.v1; patent:US09062032B2
反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: By using 23 mg of methyl 4-[2-(4-{[(2-{[3-(chloromethyl)benzoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)carbonyl]amino}phenyl)ethyl]benzoate and 19 mg of methyl[(1-ethylpropyl)amino]acetate as starting materials, alkylation was performed under the conditions similar to Preparation Example 30, and then hydrolysis was performed under the conditions similar to Example 6, thereby obtaining 6.7 mg of 4-(2-{4-[({2-[(3-{[(carboxymethyl)(pentan-3-yl)amino]methyl}benzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophen-3-yl}carbonyl)amino]phenyl}ethyl)benzoic acid. was performed under the conditions similar to Preparation Example 30 hydrolysis
来源 ID: ord-284ab43af6a9407a972899490bca3b39