5-chloro-2-isothiocyanatobenzonitrile

反应条件: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 2-(2-pyrrolyl)-5-thiono-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazoline (4.28 g), prepared from 5-chloro-2-isothiocyanatobenzonitrile and 2-pyrrolecarbohydrazide as described in Example 39, is placed in a stainless steel pressure vessel with 40% aqueous methylamine saturated at 0° with methylamine gas (225 ml) and heated 6 hours at an outside temperature of 150° C. The reaction mixture is cooled to room temperature and the solid collected, washed with water and air dried. Recrystallization from aqueous methanol, then water affords pure 5-methylimino-5,6-dihydro-2-(2-pyrrolyl)-[1,2,4]triazolo-[1,5-c]quinazoline, mp 220°-221°. The reaction mixture is cooled to room temperature the solid collected washed with water and air dried Recrystallization from aqueous methanol

反应条件: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 2-(2-pyrrolyl)-5-thiono-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazoline (4.28 g), prepared from 5-chloro-2-isothiocyanatobenzonitrile and 2-pyrrolecarbohydrazide as described in Example 39, is placed in a stainless steel pressure vessel with 40% aqueous methylamine saturated at 0° with methylamine gas (225 ml) and heated 6 hours at an outside temperature of 150° C. The reaction mixture is cooled to room temperature and the solid collected, washed with water and air dried. Recrystallization from aqueous methanol, then water affords pure 5-methylimino-5,6-dihydro-2-(2-pyrrolyl)-[1,2,4]triazolo-[1,5-c]quinazoline, mp 220°-221°. The reaction mixture is cooled to room temperature the solid collected washed with water and air dried Recrystallization from aqueous methanol

反应条件: temp:150.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 2-(2-pyrrolyl)-5-thiono-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazoline (4.28 g), prepared from 5-chloro-2-isothiocyanatobenzonitrile and 2-pyrrolecarbohydrazide as described in Example 39, is placed in a stainless steel pressure vessel with 40% aqueous methylamine saturated at 0° with methylamine gas (225 ml) and heated 6 hours at an outside temperature of 150° C. The reaction mixture is cooled to room temperature and the solid collected, washed with water and air dried. Recrystallization from aqueous methanol, then water affords pure 5-methylimino-5,6-dihydro-2-(2-pyrrolyl)-[1,2,4]triazolo-[1,5-c]quinazoline, mp 220°-221°. The reaction mixture is cooled to room temperature the solid collected washed with water and air dried Recrystallization from aqueous methanol