2-(三氟甲氧基)苄溴

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-trifluoromethoxybenzyl chloride (0.331 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 202 mg of the product 215. 1H NMR (DMSO-d6) δ 11.32 (s, 2 H), 7.85 (d, 1 H), 7.70-7.40 (m, 3 H), 7.20-6.70 (m, 10 H), 5.80 (s, 2 H), 4.85 (s, 2 H); MS: m/z 429 (M++1). evaporated to dryness The insoluble material is filtered

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-trifluoromethoxybenzyl chloride (0.331 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 202 mg of the product 215. 1H NMR (DMSO-d6) δ 11.32 (s, 2 H), 7.85 (d, 1 H), 7.70-7.40 (m, 3 H), 7.20-6.70 (m, 10 H), 5.80 (s, 2 H), 4.85 (s, 2 H); MS: m/z 429 (M++1). evaporated to dryness The insoluble material is filtered

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-trifluoromethoxybenzyl chloride (0.331 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 202 mg of the product 215. 1H NMR (DMSO-d6) δ 11.32 (s, 2H), 7.85 (d, 1H), 7.70-7.40 (m, 3H), 7.20-6.70 (m, 10H), 5.80 (s, 2H), 4.85 (s, 2H); MS: m/z 429 (M++1). evaporated to dryness The insoluble material is filtered

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-trifluoromethoxybenzyl chloride (0.331 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 202 mg of the product 215. 1H NMR (DMSO-d6) δ 11.32 (s, 2 H), 7.85 (d, 1 H), 7.70-7.40 (m, 3 H), 7.20-6.70 (m, 10 H), 5.80 (s, 2 H), 4.85 (s, 2 H); MS: m/z 429 (M++1). evaporated to dryness The insoluble material is filtered