5-氨基-2-甲基异吲哚啉-1-酮

反应条件: temp:79.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The 2-methyl-5-nitroisoindolin-1-one (50 mg, 0.26 mmol) was dissolved in EtOH (1.3 ml) with heating, and tin chloride (117 mg, 0.52 mmol) added. The solution was stirred at 79° C. for 2 hours. The mixture was cooled to RT, diluted with 4:1 water:saturated sodium bicarbonate (aq, 100 ml), extracted with EtOAc (3×100 ml), the organics combined, washed with brine, dried over Na2SO4, filtered and the volatiles removed in vacuum. The product was purified by chromatography on SiO2 eluting with 5% MeOH:DCM+1% TEA to give the titled compound. with heating The mixture was cooled to RT saturated sodium bicarbonate (aq, 100 ml), extracted with EtOAc (3×100 ml) washed with brine dried over Na2SO4 filtered the volatiles removed in vacuum The product was purified by chromatography on SiO2 eluting with 5% MeOH

反应条件: temp:79.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The 2-methyl-5-nitroisoindolin-1-one (50 mg, 0.26 mmol) was dissolved in EtOH (1.3 ml) with heating, and tin chloride (117 mg, 0.52 mmol) added. The solution was stirred at 79° C. for 2 hours. The mixture was cooled to RT, diluted with 4:1 water:saturated sodium bicarbonate (aq, 100 ml), extracted with EtOAc (3×100 ml), the organics combined, washed with brine, dried over Na2SO4, filtered and the volatiles removed in vacuum. The product was purified by chromatography on SiO2 eluting with 5% MeOH:DCM+1% TEA to give the titled compound. with heating The mixture was cooled to RT saturated sodium bicarbonate (aq, 100 ml), extracted with EtOAc (3×100 ml) washed with brine dried over Na2SO4 filtered the volatiles removed in vacuum The product was purified by chromatography on SiO2 eluting with 5% MeOH

反应条件: temp:79.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The 2-methyl-5-nitroisoindolin-1-one (50 mg, 0.26 mmol) was dissolved in EtOH (1.3 ml) with heating, and tin chloride (117 mg, 0.52 mmol) added. The solution was stirred at 79° C. for 2 hours. The mixture was cooled to RT, diluted with 4:1 water:saturated sodium bicarbonate (aq, 100 ml), extracted with EtOAc (3×100 ml), the organics combined, washed with brine, dried over Na2SO4, filtered and the volatiles removed in vacuum. The product was purified by chromatography on SiO2 eluting with 5% MeOH:DCM+1% TEA to give the titled compound. with heating The mixture was cooled to RT saturated sodium bicarbonate (aq, 100 ml), extracted with EtOAc (3×100 ml) washed with brine dried over Na2SO4 filtered the volatiles removed in vacuum The product was purified by chromatography on SiO2 eluting with 5% MeOH