甲基 N-氰基环丙烷甲亚氨酸甲酯

反应条件: temp:10.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: At 0° C. 8,4 g of cyanamide in 50 ml methanol are added to 36 g of a 30% solution of sodium methylate in methanol and stirred for 30 min. at 10° C. The resulting solution is then cooled to -20° C. and mixed with a solution of 22 g N-cyano-cyclopropanecarboximidic acid methylester in 60 ml methanol. The reaction mixture is then stirred for 30 min. at 20° C. and then evaporated. 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation. Then again 100 ml of toluene is added and the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g. At 0° C The resulting solution is then cooled to -20° C. The reaction mixture is then stirred for 30 min. at 20° C. evaporated 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation Then again 100 ml of toluene is added the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g

反应条件: temp:10.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: At 0° C. 8,4 g of cyanamide in 50 ml methanole are added to 36 g of a 30% solution of sodium methylate in methanol and stirred for 30 min. at 10° C. The resulting solution is then cooled to -20° C. and mixed with a solution of 22 g N-cyano-cyclopropanecarboximidic acid methylester in 60 ml methanole. The reaction mixture is then stirred for 30 min. at 20° C. and then evaporated. 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation. Then again 100 ml of toluene is added and the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g. At 0° C The resulting solution is then cooled to -20° C. The reaction mixture is then stirred for 30 min. at 20° C. evaporated 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation Then again 100 ml of toluene is added the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g

反应条件: temp:10.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: At 0° C. 8,4 g of cyanamide in 50 ml methanole are added to 36 g of a 30% solution of sodium methylate in methanol and stirred for 30 min. at 10° C. The resulting solution is then cooled to -20° C. and mixed with a solution of 22 g N-cyano-cyclopropanecarboximidic acid methylester in 60 ml methanole. The reaction mixture is then stirred for 30 min. at 20° C. and then evaporated. 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation. Then again 100 ml of toluene is added and the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g. At 0° C The resulting solution is then cooled to -20° C. The reaction mixture is then stirred for 30 min. at 20° C. evaporated 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation Then again 100 ml of toluene is added the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g

反应条件: temp:10.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: At 0° C. 8,4 g of cyanamide in 50 ml methanol are added to 36 g of a 30% solution of sodium methylate in methanol and stirred for 30 min. at 10° C. The resulting solution is then cooled to -20° C. and mixed with a solution of 22 g N-cyano-cyclopropanecarboximidic acid methylester in 60 ml methanol. The reaction mixture is then stirred for 30 min. at 20° C. and then evaporated. 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation. Then again 100 ml of toluene is added and the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g. At 0° C The resulting solution is then cooled to -20° C. The reaction mixture is then stirred for 30 min. at 20° C. evaporated 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation Then again 100 ml of toluene is added the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g

反应条件: temp:10.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: At 0° C. 8,4 g of cyanamide in 50 ml methanol are added to 36 g of a 30% solution of sodium methylate in methanol and stirred for 30 min. at 10° C. The resulting solution is then cooled to -20° C. and mixed with a solution of 22 g N-cyano-cyclopropanecarboximidic acid methylester in 60 ml methanol. The reaction mixture is then stirred for 30 min. at 20° C. and then evaporated. 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation. Then again 100 ml of toluene is added and the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g. At 0° C The resulting solution is then cooled to -20° C. The reaction mixture is then stirred for 30 min. at 20° C. evaporated 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation Then again 100 ml of toluene is added the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g

反应条件: temp:10.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: At 0° C. 8,4 g of cyanamide in 50 ml methanole are added to 36 g of a 30% solution of sodium methylate in methanol and stirred for 30 min. at 10° C. The resulting solution is then cooled to -20° C. and mixed with a solution of 22 g N-cyano-cyclopropanecarboximidic acid methylester in 60 ml methanole. The reaction mixture is then stirred for 30 min. at 20° C. and then evaporated. 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation. Then again 100 ml of toluene is added and the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g. At 0° C The resulting solution is then cooled to -20° C. The reaction mixture is then stirred for 30 min. at 20° C. evaporated 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation Then again 100 ml of toluene is added the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g

反应条件: temp:10.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: At 0° C. 8,4 g of cyanamide in 50 ml methanol are added to 36 g of a 30% solution of sodium methylate in methanol and stirred for 30 min. at 10° C. The resulting solution is then cooled to -20° C. and mixed with a solution of 22 g N-cyano-cyclopropanecarboximidic acid methylester in 60 ml methanol. The reaction mixture is then stirred for 30 min. at 20° C. and then evaporated. 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation. Then again 100 ml of toluene is added and the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g. At 0° C The resulting solution is then cooled to -20° C. The reaction mixture is then stirred for 30 min. at 20° C. evaporated 100 ml of dioxane is added to the resulting residue which is then concentrated by evaporation Then again 100 ml of toluene is added the solution is concentrated at an ambient temperature of 60° C. up to a residual weight of 33 g