暂无可渲染的结构数据
C1=CC(=C(C=C1Br)F)CC(F)(F)F中间体产品
4-bromo-2-fluoro-1-(2,2,2-trifluoroethyl)benzene
结构、标识符和计算性质已按 CAS 与数据库记录完成匹配。
| 中文名称 | 4-溴-2-氟-1-(2,2,2-三氟乙基)苯 |
|---|---|
| English name | 4-bromo-2-fluoro-1-(2,2,2-trifluoroethyl)benzene |
| IUPAC 名称 | — |
| CAS号 | 1256841-61-8 |
| 数据库编号 | 54310924 |
| 分子式 | — |
| 分子量 | — |
产品信息
4-溴-2-氟-1-(2,2,2-三氟乙基)苯（CAS 1256841-61-8）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
可能的应用方向
仅供专业研发与工业用途
数据库编号 54310924
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合成路线数据
5 条反应 · 5 篇文献
反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-50b345e2e0c243a8aaa59c4cbbba2be2反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of 6.78 g (23.7 mmol, purity 90%) of the compound from Example 74A in toluene (339 ml) was admixed under argon at RT with 7.74 g (35.6 mmol) of the compound from Example 29A in ethanol (112 ml) and 3.61 g (26.1 mmol) of potassium carbonate. After stirring for 10 min, 2.74 g (2.37 mmol) of tetrakis(triphenylphosphine)palladium and then 4.14 g (71.2 mmol) of potassium fluoride in water (71 ml) were added. The mixture was stirred under reflux for 8 h, and the reaction solution was cooled and diluted with ethyl acetate. The reaction solution was washed in water, and the organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. The residue was purified by means of column chromatography (silica gel, dichloromethane, dichloromethane/methanol 150:1→100:1). The product fractions were concentrated under reduced pressure and the solid obtained was purified by stirring with diethyl ether. Yield: 6.00 g (50% of theory, purity 62%) The mixture was stirred under reflux for 8 h the reaction solution was cooled The reaction solution was washed in water the organic phase was dried over magnesium sulphate filtered concentrated under reduced pressure The residue was purified by means of column chromatography (silica gel, dichloromethane, dichloromethane/methanol 150:1→100:1) The product fractions were concentrated under reduced pressure the solid obtained was purified by stirring with diethyl ether
来源 ID: ord-0f85fc2012e24b76bfc6449bd39a0e12反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of 6.78 g (23.7 mmol, purity 90%) of the compound from Example 74A in toluene (339 ml) was admixed under argon at RT with 7.74 g (35.6 mmol) of the compound from Example 29A in ethanol (112 ml) and 3.61 g (26.1 mmol) of potassium carbonate. After stirring for 10 min, 2.74 g (2.37 mmol) of tetrakis(triphenylphosphine)palladium and then 4.14 g (71.2 mmol) of potassium fluoride in water (71 ml) were added. The mixture was stirred under reflux for 8 h, and the reaction solution was cooled and diluted with ethyl acetate. The reaction solution was washed in water, and the organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. The residue was purified by means of column chromatography (silica gel, dichloromethane, dichloromethane/methanol 150:1→100:1). The product fractions were concentrated under reduced pressure and the solid obtained was purified by stirring with diethyl ether. Yield: 6.00 g (50% of theory, purity 62%) The mixture was stirred under reflux for 8 h the reaction solution was cooled The reaction solution was washed in water the organic phase was dried over magnesium sulphate filtered concentrated under reduced pressure The residue was purified by means of column chromatography (silica gel, dichloromethane, dichloromethane/methanol 150:1→100:1) The product fractions were concentrated under reduced pressure the solid obtained was purified by stirring with diethyl ether
来源 ID: ord-0f85fc2012e24b76bfc6449bd39a0e12反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-50b345e2e0c243a8aaa59c4cbbba2be2反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of 6.78 g (23.7 mmol, purity 90%) of the compound from Example 74A in toluene (339 ml) was admixed under argon at RT with 7.74 g (35.6 mmol) of the compound from Example 29A in ethanol (112 ml) and 3.61 g (26.1 mmol) of potassium carbonate. After stirring for 10 min, 2.74 g (2.37 mmol) of tetrakis(triphenylphosphine)palladium and then 4.14 g (71.2 mmol) of potassium fluoride in water (71 ml) were added. The mixture was stirred under reflux for 8 h, and the reaction solution was cooled and diluted with ethyl acetate. The reaction solution was washed in water, and the organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. The residue was purified by means of column chromatography (silica gel, dichloromethane, dichloromethane/methanol 150:1→100:1). The product fractions were concentrated under reduced pressure and the solid obtained was purified by stirring with diethyl ether. Yield: 6.00 g (50% of theory, purity 62%) The mixture was stirred under reflux for 8 h the reaction solution was cooled The reaction solution was washed in water the organic phase was dried over magnesium sulphate filtered concentrated under reduced pressure The residue was purified by means of column chromatography (silica gel, dichloromethane, dichloromethane/methanol 150:1→100:1) The product fractions were concentrated under reduced pressure the solid obtained was purified by stirring with diethyl ether
来源 ID: ord-0f85fc2012e24b76bfc6449bd39a0e12PubChem References
以下资料来自该化合物的公开数据库参考记录。