甲基 2-异氰酸根合-2-苯基乙酸酯

反应条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2.8 g (12 mmol) of (3-tert-butoxycarbonylaminopropyl)glycine and 1.4 g (12 mmol) of N-ethylmorpholine are dissolved in 300 ml of dimethylformamide. 2.3 g (12 mmol) of methyl α-isocyanatophenylacetate are added dropwise at 100° C. The mixture is stirred at 100° C. for 1 h, allowed to cool down to room temperature, concentrated and chromatographed on silica gel using ethyl acetate/methanol 8:2. to cool down to room temperature concentrated chromatographed on silica gel