三氟甲醇

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 4-Chloro-N-((R/S)-5-((R/S)-4,4,4-trifluoro-3-hydroxybutyl)-1,2,3,4-tetrahydronaphthalen-2-yl)benzenesulfonamide, designated as (+/−)-22/(+/−)-22 in FIG. 10, was prepared as follows. Dess-Martin periodinane (128.8 mg, 0.30 mmol) was added to a solution of the trifluoromethyl alcohol (67.6 mg, 0.15 mmol) in dichloromethane (4 mL) and the reaction was stirred at room temperature for 2 hour. The reaction mixture was diluted with dichloromethane and washed with water. The organic layer was separated, dried over magnesium sulfate and concentrated to dryness. Silica gel chromatography (20% ethyl acetate in hexanes), gave the purified product, (R/S)-4-chloro-N-(5-(4,4,4-trifluoro-3-oxobutyl)-1,2,3,4-tetrahydronaphthalen-2-yl)benzenesulfonamide, as colorless oil (51.1 mg). Yield 76%. was prepared washed with water The organic layer was separated dried over magnesium sulfate concentrated to dryness