2-(2-甲氧乙氧基)乙酸甲酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 34.4 grams of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine, 29.6 grams of methyl 2-methoxyethoxyacetate and 300 mL of heptane are transferred to a 500 mL 3-necked, round-bottomed flask equipped with a mechanical stirrer, Dean-Stark trap and condenser. Trace amounts of water are removed by azeotropic distillation. 0.25 mL of tetraisopropyl orthotitanate is added to the reaction mixture. The reaction mixture is refluxed for six hours and the liberated methanol is collected in the Dean-Stark trap. The reaction mixture is allowed to cool and is then partitioned between 300 mL of ethyl acetate and 300 mL of water. The phases are separated and the organic phase is washed with water and dried over anhydrous magnesium sulfate. Evaporation of the solvent leaves the title compound as a red oil. round-bottomed flask equipped with a mechanical stirrer Trace amounts of water are removed by azeotropic distillation 0.25 mL of tetraisopropyl orthotitanate is added to the reaction mixture The reaction mixture is refluxed for six hours the liberated methanol is collected in the Dean-Stark trap to cool is then partitioned between 300 mL of ethyl acetate and 300 mL of water The phases are separated the organic phase is washed with water dried over anhydrous magnesium sulfate Evaporation of the solvent

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 34.4 grams of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine, 29.6 grams of methyl 2-methoxyethoxyacetate and 300 mL of heptane are transferred to a 500 mL 3-necked, round-bottomed flask equipped with a mechanical stirrer, Dean-Stark trap and condenser. Trace amounts of water are removed by azeotropic distillation. 0.25 mL of tetraisopropyl orthotitanate is added to the reaction mixture. The reaction mixture is refluxed for six hours and the liberated methanol is collected in the Dean-Stark trap. The reaction mixture is allowed to cool and is then partitioned between 300 mL of ethyl acetate and 300 mL of water. The phases are separated and the organic phase is washed with water and dried over anhydrous magnesium sulfate. Evaporation of the solvent leaves the title compound as a red oil. round-bottomed flask equipped with a mechanical stirrer Trace amounts of water are removed by azeotropic distillation 0.25 mL of tetraisopropyl orthotitanate is added to the reaction mixture The reaction mixture is refluxed for six hours the liberated methanol is collected in the Dean-Stark trap to cool is then partitioned between 300 mL of ethyl acetate and 300 mL of water The phases are separated the organic phase is washed with water dried over anhydrous magnesium sulfate Evaporation of the solvent