2-羟基-2-(三氟甲基)丁腈

反应条件: temp:115.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Concentrated sulfuric acid (15.3 g) was added, under an argon atmosphere, to a 100 ml flask and the starting compound 3,3,3-trifluoro-2-hydroxy-2-ethylpropiononitrile (Fluorchem) (8 g) was then added dropwise. The reaction mixture was heated at 115° C. for 15 min and then cooled down to 8° C.; distilled water (21.8 g) was then added slowly. Diethyl ether was then added and the whole was stirred for 20 min. cooled down to 8° C.