β-D-吡喃葡萄糖基叠氮化物

反应条件: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Composition 4 (3.05 g) was dissolved in dry pyridine (50 ml), chlorotriphenyl-methane (5.01 g) was added and the reaction mixture was stirred at 70° C. for three hours. It was cooled to 0° C., acetic anhydride (6.36 ml) was added dropwise and the mixture was stirred overnight at room temperature. It was poured into ice-water and was diluted with chloroform (300 ml). The organic layer was washed subsequently with water, 2M hydrochloric acid, water, was dried and evaporated to leave 2,3,4-tri-O-acetyl-6-O-trityl-β-D-glucopyranosyl azide (5, 7.67 g, 90%). It was cooled to 0° C. the mixture was stirred overnight at room temperature The organic layer was washed subsequently with water, 2M hydrochloric acid, water was dried evaporated

反应条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl azide (3, 5.6 g) in methanol (50 ml) 1M methanolic sodium methoxide (0.5 ml) was added and the solution was stirred overnight at 0° C., then it was neutralized with AG 50W-X8 (H+) ion-exchange resin. The resin was filtered off, the filtrate was evaporated and dried in vacuo to give the known β-D-glucopyranosyl azide (4). The resin was filtered off the filtrate was evaporated dried in vacuo