4-溴-2,3-二甲基苯胺

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at from 50 to 58° C. The mixture is subsequently stirred at from 75 to 80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, the excess dimethyl disulfide is separated off at atmospheric pressure. 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered. The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, the excess dimethyl disulfide is separated off at atmospheric pressure 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80 for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80 for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at from 50 to 58° C. The mixture is subsequently stirred at from 75 to 80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, the excess dimethyl disulfide is separated off at atmospheric pressure. 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered. The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, the excess dimethyl disulfide is separated off at atmospheric pressure 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at 50-58° C. The mixture is then stirred at 75-80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, excess dimethyl disulfide is removed under atmospheric pressure. 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered. The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, excess dimethyl disulfide is removed under atmospheric pressure 1870 g of dimethyl disulfide (purity>97% according to GC) are recovered The residue is then subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at from 50 to 58° C. The mixture is subsequently stirred at from 75 to 80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, the excess dimethyl disulfide is separated off at atmospheric pressure. 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered. The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, the excess dimethyl disulfide is separated off at atmospheric pressure 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar)

反应条件: temp:77.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 603 g (5.85 mol) of tert-butyl nitrite and 375 g of copper powder (5.9 mol) are initially charged in 3000 ml of dimethyl disulfide, and 761 g (3.75 mol) of 4-bromo-2,3-dimethylaniline are added dropwise at from 50 to 58° C. The mixture is subsequently stirred at from 75 to 80° C. for 9 hours. For work-up, the mixture is cooled, the residue is filtered off and the filtrate is washed with saturated aqueous NaHCO3 solution. For purification of the product, the organic phase is separated by distillation. Initially, the excess dimethyl disulfide is separated off at atmospheric pressure. 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered. The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar). For work-up, the mixture is cooled the residue is filtered off the filtrate is washed with saturated aqueous NaHCO3 solution For purification of the product the organic phase is separated by distillation Initially, the excess dimethyl disulfide is separated off at atmospheric pressure 1870 g of dimethyl disulfide (purity >97% according to GC) are recovered The residue is subsequently subjected to fractional distillation under reduced pressure (0.1 mbar)