3-苄基咪唑烷-2,4-二酮

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-Benzylimidazolidine-2,4-dione (100 mg, 0.526 mmol) and 1-isocyanatohexane (80.2 mg, 0.63 mmol) were reacted in analogy to example 1. Yield: 19.3 mg (12%), M+H+: 318.15.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 3-benzylimidazolidin-2,4-dione (5.7 g, JACS 1965, 3414) in DMF (10 ml) was added under N2 to a stirred suspension of anhy. K2CO3 (4.1 g) in DMF (10 ml), followed by the addition of a solution of p-nitrobenzyl bromide (6.45 g, Aldrich) in DMF (10 ml). After additions were complete, the mixture was stirred at room temperature for 72 hours, then poured into ice-water and extracted with ethyl acetate (×3). The combined extracts were washed with water (×2) and brine, dried over MgSO4 and evaporated to give a yellow oil which was flash chromatographed through a silica column using chloroform to give the desired product as a pale yellow solid (7.9 g). extracted with ethyl acetate (×3) The combined extracts were washed with water (×2) and brine dried over MgSO4 evaporated to give a yellow oil which chromatographed through a silica column

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 3-benzylimidazolidin-2,4-dione (5.7 g, JACS 1965, 3414) in DMF (10 ml) was added under N2 to a stirred suspension of anhy. K2CO3 (4.1 g) in DMF (10 ml), followed by the addition of a solution of p-nitrobenzyl bromide (6.45 g, Aldrich) in DMF (10 ml). After additions were complete, the mixture was stirred at room temperature for 72 hours, then poured into ice-water and extracted with ethyl acetate (×3). The combined extracts were washed with water (×2) and brine, dried over MgSO4 and evaporated to give a yellow oil which was flash chromatographed through a silica column using chloroform to give the desired product as a pale yellow solid (7.9 g). extracted with ethyl acetate (×3) The combined extracts were washed with water (×2) and brine dried over MgSO4 evaporated to give a yellow oil which chromatographed through a silica column

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-Benzylimidazolidine-2,4-dione (100 mg, 0.526 mmol) and 1-isocyanatohexane (80.2 mg, 0.63 mmol) were reacted in analogy to example 1. Yield: 19.3 mg (12%), M+H+: 318.15.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 3-benzylimidazolidin-2,4-dione (5.7 g, JACS 1965, 3414) in DMF (10 ml) was added under N2 to a stirred suspension of anhy. K2CO3 (4.1 g) in DMF (10 ml), followed by the addition of a solution of p-nitrobenzyl bromide (6.45 g, Aldrich) in DMF (10 ml). After additions were complete, the mixture was stirred at room temperature for 72 hours, then poured into ice-water and extracted with ethyl acetate (×3). The combined extracts were washed with water (×2) and brine, dried over MgSO4 and evaporated to give a yellow oil which was flash chromatographed through a silica column using chloroform to give the desired product as a pale yellow solid (7.9 g). extracted with ethyl acetate (×3) The combined extracts were washed with water (×2) and brine dried over MgSO4 evaporated to give a yellow oil which chromatographed through a silica column